Drug helps to clear traumatic memories

NATURE | NEWS

Medication removes markers from brain’s DNA to increase effectiveness of existing treatment.

Traumatic experiences leave a signature in the brain that is hard to erase. Painflul memories of war or child abuse are recorded in DNA as chemical marks in the genome, which makes conditions such as post-traumatic stress disorder (PTSD) difficult to treat with behavioural approaches.

Now, researchers report¹ that in mice, clearing these epigenetic markers with a drug can dramatically improve the effectiveness of a common behavioural treatment for PTSD, allowing the brain to dissociate a specific memory from the emotion associated with it.

In people with PTSD or other anxiety disorders, the pain associated with a specific memory fails to subside over time, as it usually would. “Every day they’re reliving it,” says Li-Huei Tsai, a neuroscientist at the Massachusetts Institute of Technology in Cambridge, and a co-author of the study. Exposure to the memory through photos or virtual reality simulations of the traumatic event in a safe environment — part of a technique known as extinction therapy — can help to dull the pain, but people with severe PTSD tend to relapse.

To simulate the disorder, Tsai and her colleagues delivered electrical shocks to the feet of mice while playing a loud sound. When the mice had learned to associate the sound with the painful stimulus, they would freeze whenever they heard it, even if they did not receive another shock. A day after the fear-conditioning, the researchers repeatedly played the sound in a safe environment, and made the mice forget the fearful association. But when the extinction therapy was started a month after the fear-conditioning, it did not work — in part because the bad memory had become epigenetically engrained.

Combined treatment

In rodents, Tsai says, it seems to take about a week for a memory to be permanently written into the epigenome. But her work suggests that a class of drugs called histone deacetylase inhibitors (HDACis), which clear epigenetic marks from DNA, can lengthen that window.

When researchers gave the mice an HDACi before they began the extinction therapy, the drug seemed to 'prime' the epigenome, creating a brief period in which memories could be reconsolidated, or modified. The HDACi alone had no effect on the mice’s memories, but just one dose combined with extinction therapy made the mice stop freezing when they heard the traumatic sound.

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